0001193125-07-074759 Sample Contracts

ACADIA Pharmaceuticals Inc. 5,750,000 Shares Common Stock UNDERWRITING AGREEMENT dated April 4, 2007 Banc of America Securities LLC Lehman Brothers Inc. Deutsche Bank Securities Inc. Piper Jaffray & Co. JMP Securities LLC Rodman & Renshaw, LLC
Underwriting Agreement • April 5th, 2007 • Acadia Pharmaceuticals Inc • Pharmaceutical preparations • New York

The lock-up restriction described in the previous paragraph shall not apply to: (1) bona fide gifts to, or transfers to a trust for, the direct or indirect benefit of the undersigned or the immediate family of the undersigned, (2) any shares of Common Stock sold pursuant to any 10b5-1 plan existing on or prior to the date hereof, and (3) the entering into a 10b5-1 plan during the Lock-Up Period so long as no shares of Common Stock are sold pursuant to such 10b5-1 plan during the Lock-Up Period; provided that in any transaction described in clause (1) above, (x) prior to such donation, transfer or distribution, such donee, transferee, or distributee shall execute and deliver to the Representatives a duplicate form of this lock-up agreement and (y) the undersigned shall not be required to, and shall not voluntarily, file a report under Section 16(a) of the Exchange Act. For purposes of this lock-up agreement, “immediate family” shall mean any relationship by blood, marriage or adoption,

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