0000950133-03-002985 Sample Contracts

AMENDMENT NO. 3 TO RESEARCH & DEVELOPMENT AND LICENSE AGREEMENT
Development and License Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • Illinois

This Amendment No. 3 to Research & Development and License Agreement, dated as of December 23, 1997, is between Abbott Laboratories, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois (“Abbott”) and ArQule, Inc., a Delaware corporation having a principal place of business at 200 Boston Avenue, Suite 1000, Medford, Massachusetts (“ArQule”).

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AMENDMENT NO. 2 TO RESEARCH & DEVELOPMENT AND LICENSE AGREEMENT
Development and License Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • Illinois

This Amendment No. 2 to Research & Development and License Agreement is dated as of December 24, 1996 by and between Abbott Laboratories, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois (“Abbott”) and ArQule, Inc., a Delaware corporation having a principal place of business at 200 Boston Avenue, Suite 36, Medford, Massachusetts (“ArQule”).

RESEARCH & DEVELOPMENT AND LICENSE AGREEMENT
Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • Illinois

THIS AGREEMENT (“Agreement”) is made and entered into effective as of the 16th day of June, 1995 (“Effective Date”), by and between ABBOTT LABORATORIES, an Illinois corporation having a principal place of business at 100 Abbott Park Road, Abbott Park, Illinois 60064 (“Abbott”) and ARQULE, INC., a Delaware corporation having a principal place of business at 200 Boston Avenue, Suite 3600, Medford, Massachusetts 02155 (‘ArQule”).

RESEARCH AND LICENSE AGREEMENT between ARQULE, INC. and AMERICAN HOME PRODUCTS CORPORATION acting through its WYETH-AYERST RESEARCH DIVISION dated as of July 3, 1997
Research and License Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • Massachusetts

This Agreement, dated as of July 3, 1997, is between ArQule, Inc. (“ArQule”), a Delaware corporation, and American Home Products Corporation, acting through its Wyeth-Ayerst Research division (“Wyeth-Ayerst”), a Delaware corporation.

ARRAY DELIVERY AND TESTING AGREEMENT between ARQULE, INC. and MONSANTO COMPANY
Array Delivery and Testing Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • New York

This Agreement, dated as of December 23, 1996, is between ArQule, Inc. (“ArQule”), a Delaware corporation, and Monsanto Company (“Monsanto”), a Delaware corporation.

COLLABORATION AGREEMENT
Common Stock Purchase Agreement • August 19th, 2003 • Arqule Inc • Pharmaceutical preparations • New York

THIS COMMON STOCK PURCHASE AGREEMENT dated as of December 19, 2001 (the “Agreement”) is made between ARQULE, INC., a corporation organized under the laws of the State of Delaware (“ArQule” or the “Company”), and PFIZER HOLDINGS EUROPE (“Pfizer”), an unlimited liability company incorporated under the laws of the Republic of Ireland.

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