0000927016-03-001379 Sample Contracts

Contract
Employment Agreement • March 26th, 2003 • Curagen Corp • Services-commercial physical & biological research • Connecticut

THIS EMPLOYMENT AGREEMENT (“Agreement”) is made and entered into as of December 19, 2002 between 454 Corporation, a corporation organized under the laws of the State of Delaware, with its principal place of business at 20 Commercial Street, Branford, Connecticut (the “Company”), and Richard F. Begley, Ph.D. (“Executive”).

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AMENDMENT TO LEASE
To Lease • March 26th, 2003 • Curagen Corp • Services-commercial physical & biological research • Delaware

THIS AMENDMENT TO LEASE (“Amendment”) made and entered into this 23rdday of April, 2002 by and between TKJ ASSOCIATES LLC, a Connecticut limited liability company having an address at No.1 Selden Avenue, Branford, Connecticut 06405, hereinafter referred to as Landlord; and CURAGEN CORPORATION, a Delaware corporation having an office at 555 Long Wharf Drive, 11th Floor, New Haven, Connecticut 06510, hereinafter referred to as Tenant.

AMENDED AND RESTATED RESEARCH AND OPTION AGREEMENT by and between GENENTECH, INC. and CURAGEN CORPORATION March 31, 2000
Research and Option Agreement • March 26th, 2003 • Curagen Corp • Services-commercial physical & biological research • New York

Certain confidential information contained in this Exhibit, marked by brackets and asterisks, were omitted and have been filed separately with the Secretary of the Commission pursuant to the Company’s application requesting confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934.

THIRD AMENDMENT TO LEASE AGREEMENT
Lease Agreement • March 26th, 2003 • Curagen Corp • Services-commercial physical & biological research

THIS THIRD AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Third Amendment”) is made as of the 1st day of January, 2001 by and between FUSCO HARBOUR ASSOCIATES, LLC, a Connecticut limited liability company, with offices and a principal place of business c/o The Fusco Corporation, 555 Long Wharf Drive, New Haven, Connecticut 06511 (said Fusco Harbour Associates, LLC, its successors and assigns hereinafter referred to as the “Landlord”) and CURAGEN CORPORATION, a Delaware corporation with an office at 555 Long Wharf Drive, New Haven, Connecticut 06511 (said CuraGen Corporation, its successors and assigns hereinafter referred to as the “Tenant”).

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