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to WP4. 2.3 for reference purposes. Description of work Definitions: Migration modelling is now well established for many mono-layer plastics. However, the scientific basis for multi-layer migration modelling is not sufficiently developed. Migration of a chemical from a ML-FCM is controlled by the diffusion within the ML-FCM followed by the transfer into the food, F, and diffusion within this food. A model to describe this should take into account: - the diffusion coefficients, DPn , in each layer n of the FCM, - the partitioning of the substance at the interfaces of the FCM, KPn-1,Pn - the partitioning of the substance at the FCM-F interface, KPn,F, and - the diffusion coefficient, DF , of the substance in the food To establish a versatile (DPn/K)n/DF migration model the following tasks will be carried out on the basis of the experimental data provided by and in feed-back interaction with WP4.2-1 to 3: Sub-task 1. Conceptual setup of the model Sub-task 2. Mathematical solution of the model Sub-task 3. Setup of the model for plastic multi-layer materials Sub-task 4. Implementation of particular layers: paper/board, coatings, adhesives, printing inks. Sub-task 5. Demonstration of workability of the full migration model Sub-task 6. Compiling a comprehensive data set of diffusion and partition constants (D and K)
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